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Liposomal Encapsulation, what is and what are its benefits?

Liposomal Encapsulation, what is and what are its benefits?

Publicado: 29 November, 2021 - Actualizado: 14 February, 2022 | 3'

The Liposomal encapsulation technology is a transport system for the active ingredient that travels "encapsulated" in liposomes. This amazing technology works to achieve better absorption and utilisation of the active ingredient within the body.

Liposome encapsulation is applied in the pharmaceutical and food supplement sector offering many advantages for consumers of nutritional supplements.

What are Liposomes?

LiposomaLiposomes are microscopic hollow spherical vesicles, composed of two layers of lipids (fatty acids).

The main constituents of liposomes are phospholipids, which bear the characteristic of having one side soluble in fat and the other side soluble in water (amphipathic molecule).

This property of phospholipids gives liposomes unique characteristics

such as self-sealing in aqueous mediums and makes them a perfect carrier system.

In this way, they act as delivery vehicles for a broad spectrum of bioactive compounds. In their aqueous core they can carry hydrophilic nutrients such as vitamins and plant extracts. They are therefore an ideal carrier with applications in different fields such as food, cosmetics, agriculture, and pharmaceuticals.

Liposomes History 

Liposomes were synthetically manufactured for the first time in England in 1961 by Alec D. Bangham, who discovered that phospholipids combined with water form a sphere because one end of each molecule is soluble in fat, whereas the opposite end is insoluble in water.

Advantages of Liposomal technology

Improves bioavailability

Encapsulation in liposomes ensures that the active ingredients reach the bloodstream (bioavailability) by providing solubilisation and protection.

Facilitates the absorption of active­ingredients

This is due to the fact that the phospholipids forming the liposomes allow absorption to take place in the intestine, protecting the formulation from the action of gastric acids.

Improves the stability of the active ingredient in the body

The liposomal technology facilitates the absorption of the active ingredient in the intestine and protects the compounds from premature degradation in the gastrointestinal tract, thus favouring the stability of the ingredient and its beneficial effects.

Allows advanced release

A significant advantage of the liposome is that it can incorporate and release two materials with different solubility simultaneously.

Liposomal food supplements

Thanks to this unique encapsulation technology, liposomal supplements provide high availability and sustainability of blood levels of the active ingredient.

Most common Liposomal dietary supplements can be oral vitamins and minerals supplement formulations, either in liquid or capsule forms, or other delivery formulations.

Liposomal Vitamin C

For example, in a vitamin C supplement such as liposomal vitamin C, encapsulating this active ingredient allows for better stability of vitamin C in the body. In other words, the vitamin C within the liposomes 'lasts' longer than when taken in other standard forms.

Liposomal Magnesium

Magnesium is a mineral that can be found in food and in liposomal magnesium supplements. It has health-promoting properties that contribute to normal musculoskeletal function and the application of liposomal technology is intended to improve bioavailability.

When magnesium salts are added to the liposome, the bioavailability of the active ingredient is increased, as the phospholipids improve nutrient absorption by forming a protective barrier against gastric acid and digestive enzymes, also contributing to digestion.

Liposomal L-Carnitine

L-carnitine is a natural compound widely used in sports, as an ally of physical performance and muscular energy. When presented in liposomal L-carnitine supplements, L-carnitine is absorbed in the small intestine, increasing its bioavailability and promoting its activity in the body.

The use of the liposome as a vehicle for transporting L-carnitine for intestinal absorption is therefore very efficient for L-carnitine to exert the desired effect.

Liposomal Melatonin

Both melatonin secretion and sleep quality tend to decline with age. Melatonin can be found in both food and dietary supplements and helps people to fall asleep. Liposomal melatonin supplements and the liquid liposomal form improve the absorption and bioavailability of melatonin in the body.